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Key Takeaways GHK-Cu (glycyl-L-histidyl-L-lysine copper complex) is a naturally occurring tripeptide found in human plasma, saliva, and urine

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Integrating metabolomics, stable isotope tracing and biophysical studies of the interaction between spermine and Fe 2+ ions, we demonstrate that aldehyde dehydrogenase 18 family member A1 (ALDH18A1) promotes an alternative glutamine-dependent pathway for de novo spermine synthesis