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The cellular antioxidant system plays a central role in regulating both metabolic stress and inflammation, wherein oxidative molecules are directly controlled by the reducing nature of NAPDH.21, 60 In the cellular antioxidant system, NADPH is required for reducing the oxidized-glutathione, which otherwise fails to control the production of ROS and thus causes oxidative damage to cells.60, 61 Studies have shown that mice deficient in G6PD showing enhanced sensitivity to even mild oxidative stress.62, 63 These findings further suggest the importance of G6PD in the synthesis of NADPH, controlling metabolic stress & ROS generation and thus preventing cell damages

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Pandya A, Berneburg M, Ortonne JP, Picardo M