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PMCID: PMC7037223 Khavinson VKh, Kuznik BI, Tarnovskaia SI, Lin'kova NS

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In 90% of hereditary cases of ALS, patients have mutations in the superoxide dismutase 1 (SOD1) enzyme which converts O 2 •− to H 2 O 2 and O 2 to protect cells from ROS, and is directly associated with oxidative stress and inflammation [180]