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In mouse models of high‑fat diet‑induced liver steatosis, it significantly inhibits hepatic NNMT activity, reduces NAM methylation, increases NAD+ and SAM levels, enhances mitochondrial fatty acid oxidation, reduces hepatic triglyceride and lipid accumulation, lowers lipotoxicity markers (e.g., malondialdehyde, transaminases), improves hepatocellular injury, and reverses steatosis
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This clinical study showed that Glutathione supplementation significantly increased Glutathione levels, reduced oxidative stress markers, and improved immune function