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A 2023 observational study of 47 patients using both agent classes reported modest synergistic weight loss (additional 3–5 lbs over 12 weeks compared to single-agent) but also a 34% incidence of nausea, dizziness, or appetite suppression beyond baseline tirzepatide side effects

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This can lead to build-up of toxins in the liver and other organs, damage to cells requiring more cellular repair, and the inability of energy production