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Copper coordination chemistry, briefly What makes GHK-Cu distinctive is how the tripeptide binds copper(II): the imidazole nitrogen of histidine, the N-terminal amine, and backbone nitrogens form a coordination geometry that holds the metal ion with high affinity

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The urinary concentration of LTD4, which is usually not detectable in urine, was highly increased, whereas LTE4, the major urinary leukotriene metabolite in humans, was absent in this patient