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Planned clinical study • Objective: Determine effectiveness of a treatment to lift the methylation cycle block • 100 patients, satisfying diagnostic criteria for both CFS and fibromyalgia, in one practice (Neil Nathan, M.D., Springfield, MO) • Informed consent • Lab testing (2X): Methylation panel, characterization of certain polymorphisms, thyroid panel including autoantibodies • Questionnaires to collect pertinent data and evaluate symptoms (3X) • Treatment—”simplified treatment approach” (five supplements daily) • Patient logs • Treatment duration—six months This study will not be randomized, doubly blinded, or placebo controlled, but hopefully it will demonstrate that the treatment is worthy of a more controlled study