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Reduced glutathione ameliorates sepsis-induced acute kidney injury in mouse model: involvement of cuproptosis - PMC

Biomedicines 2022;10:1868

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Interestingly, we found increased interstitial fibrosis and vascular abnormalities consistent with inflammation and fibrosis in coronary and aortic sections from older GPx1 +/− mice [39], illustrating the detrimental effects of chronic oxidative stress on the vasculature