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There was no significant difference in the incidence of adverse events and serious adverse events in patients with diabetic neuropathy who took 600 mg/day of lipoic acid for four years compared to those in the placebo group (78)

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4.1 Evidence from epidemiological and clinical studies Large-scale human studies have consistently demonstrated robust associations between EED exposure and deterioration in fundamental reproductive parameters, including sperm concentration, motility, and DNA integrity